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Chronic Myelogenous Leukemia (CML)

Introduction

Chronic Myelogenous Leukemia (CML) is a myeloproliferative disorder characterized by increased proliferation of the granulocytic cell line without the loss of their capacity to differentiate. Consequently, the peripheral blood cell profile shows an increased number of granulocytes and their immature precursors, including occasional blast cells. CML is an acquired abnormality that derives from the hematopoietic stem cell. It is characterized by a cytogenetic aberration consisting of a reciprocal translocation between the long arms of chromosomes 22 and 9; t(9;22).

CML is a rare form of leukemia. The incidence of CML in persons up to age 70 is approximately 2 cases per 100,000. The incidence increases to about 8-13 cases per 100,000 in persons aged 80 years and older.  Since CML is rarer than the other major types of leukemia, epidemiologic studies have limited ability to evaluate causal factors of the disease. The disease is too rare to adequately study in cohort studies, so the available epidemiologic data is from case-control studies.

Chemical Exposure Causes

Benzene exposure is commonly linked to Chronic Myelogenous Leukemia.

Occupational Hazards and Exposure Hazards

Auto mechanics and industrial workers with exposure to petroleum-based products are at risk for chemical exposure to benzene.

Current Legal Cases

Metzger Law Group is currently settling cases against Safety–Kleen for individuals exposed to benzene using their defective parts washer machines.

Our Lawyers Can Help!

If you have questions about benzene poisoning or blood disorder symptoms and are concerned about possible occupational diseases and cancers, we are here to help. Toxic tort and injury laws are complex and confusing. The Metzger Law Group is here to help you. Call us today for a FREE evaluation to find out if you have a case or fill out our free evaluation forms to consult with a member of our caring staff.